Eosinophil mediated immunity

Across TCGA cell cohorts, RNA activity of the Eosinophil mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT2A, HELZ, and SBDS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MT2A grouped by Eosinophil mediated immunity-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MT2A →	+2.127	+0.932	.004	.001	3	5
SKIN	HELZ →	-0.677	-1.012	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SBDS →	+0.615	+0.733	<.001	.003	3	4
KIDNEY	SLC38A9 →	+0.888	+1.330	.003	.006	3	4
SKIN	MEGF9 →	-0.745	-0.835	.001	.004	3	3
LUNG_NSCLC_LUAD	CD274 →	+1.534	+1.001	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MT2A by Eosinophil mediated immunity activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →