Neutrophil mediated immunity

Across TCGA patient cohorts, RNA activity of the Neutrophil mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALOX5, IL4I1, and MNDA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil mediated immunity activity versus ALOX5 in GBM (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALOX5 →	+0.685	+0.068	<.001	<.001	3	8
CCRCC	IL4I1 →	+0.630	+0.041	<.001	.006	3	8
GBM	MNDA →	+1.358	+0.093	<.001	<.001	3	8
UCEC	NCF2 →	+0.557	+0.055	<.001	<.001	3	8
GBM	FMNL1 →	+0.624	+0.074	<.001	<.001	3	8
GBM	AMPD3 →	+0.677	+0.069	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002446 vs ALOX5 — GBM

Explore this scatter interactively →