Neutrophil mediated immunity

Across TCGA patient cohorts, RNA activity of the Neutrophil mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEFV, BCL2A1, and FPR2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil mediated immunity activity versus MEFV in LSCC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEFV →	+0.672	+0.226	<.001	<.001	3	8
COAD	BCL2A1 →	+1.135	+0.135	.007	.007	3	8
LSCC	FPR2 →	+1.172	+0.347	<.001	<.001	3	8
COAD	FPR1 →	+1.057	+0.139	.004	.005	3	8
COAD	SLC11A1 →	+1.110	+0.172	<.001	<.001	3	8
GBM	FGR →	+0.692	+0.188	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002446 vs MEFV — LSCC

Explore this scatter interactively →