Neutrophil mediated immunity

Across TCGA cell cohorts, RNA activity of the Neutrophil mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR1, ANXA3, and ZYX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil mediated immunity activity versus WDR1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	WDR1 →	+1.018	+1.227	.005	.001	3	6
LUNG_NSCLC_LUAD	ANXA3 →	+2.962	+0.641	<.001	.002	3	6
BLOOD_Lymphoma	ZYX →	+3.291	+0.758	<.001	.009	3	6
PANCREAS	FRMD6 →	+1.852	+0.250	.001	.004	2	6
URINARY_TRACT	LRRFIP2 →	+1.053	+1.369	<.001	.001	3	5
BREAST	IKBIP →	+1.529	+0.853	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002446 vs WDR1 — UPPER_AERODIGESTIVE_TRACT

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