Type II hypersensitivity

Across TCGA patient cohorts, RNA activity of the Type II hypersensitivity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IP6K2, BRD3, and ACIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Type II hypersensitivity activity versus IP6K2 in BRCA (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IP6K2 →	-0.446	-0.115	.001	.002	3	5
CCRCC	BRD3 →	-0.442	-0.492	<.001	.001	3	4
LSCC	ACIN1 →	-0.285	-0.117	.001	.001	3	4
GBM	TNFSF13B →	+0.652	+0.207	.003	<.001	3	4
LSCC	IL4I1 →	+0.829	+0.169	<.001	<.001	3	4
GBM	MS4A4A →	+0.989	+0.166	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002445 vs IP6K2 — BRCA

Explore this scatter interactively →