Type II hypersensitivity

Across TCGA cell cohorts, RNA activity of the Type II hypersensitivity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BOD1, NRP2, and FAM117B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BOD1 grouped by Type II hypersensitivity-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BOD1 →	+0.519	+0.790	.009	.005	3	5
BLOOD_Leukemia	NRP2 →	+1.722	+1.324	.007	.001	3	4
BREAST	FAM117B →	+0.598	+0.777	.003	<.001	3	4
SOFT_TISSUE	OTUD4 →	+0.628	+1.365	.002	.001	3	3
SOFT_TISSUE	MTSS1 →	+1.960	+1.144	<.001	<.001	3	3
BLOOD_Myeloma	MICALL1 →	-0.807	-1.078	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BOD1 by Type II hypersensitivity activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →