Myeloid leukocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Myeloid leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEFV, LILRB2, and FPR2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid leukocyte mediated immunity activity versus MEFV in HNSC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MEFV →	+0.709	+0.200	.001	<.001	3	9
HNSC	LILRB2 →	+0.932	+0.241	<.001	<.001	3	8
PDAC	FPR2 →	+1.206	+0.210	<.001	<.001	3	8
HNSC	LILRA5 →	+1.194	+0.276	<.001	<.001	3	8
UCEC	CEACAM3 →	+0.983	+0.288	<.001	<.001	3	7
LUAD	ADGRG3 →	+1.013	+0.240	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002444 vs MEFV — HNSC

Explore this scatter interactively →