Myeloid leukocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Myeloid leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFYVE16, DNAJC25, and MPHOSPH6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid leukocyte mediated immunity activity versus ZFYVE16 in BLOOD_Myeloma (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZFYVE16 →	+0.746	+0.317	.009	.008	3	4
SKIN	DNAJC25 →	+0.437	+0.464	.004	.003	3	4
LUNG_SCLC	MPHOSPH6 →	-0.777	-0.748	.007	.005	3	4
LUNG_SCLC	EVI5L →	+1.129	+0.832	.001	.002	3	4
KIDNEY	PPP1R9B →	+0.941	+0.285	.005	.004	3	4
URINARY_TRACT	CTSA →	+1.113	+1.689	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002444 vs ZFYVE16 — BLOOD_Myeloma

Explore this scatter interactively →