Acute inflammatory response to antigenic stimulus

Across TCGA patient cohorts, RNA activity of the Acute inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRE2, PIK3CG, and CSF3R, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acute inflammatory response to antigenic stimulus activity versus ADGRE2 in OV (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ADGRE2 →	+0.729	+0.204	<.001	.002	3	9
LSCC	PIK3CG →	+0.881	+0.241	<.001	<.001	3	8
LSCC	CSF3R →	+1.110	+0.279	<.001	<.001	3	8
LSCC	CCRL2 →	+0.688	+0.212	<.001	<.001	3	7
OV	PIK3R5 →	+0.860	+0.238	<.001	<.001	3	7
LSCC	NCF1 →	+0.646	+0.218	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002438 vs ADGRE2 — OV

Explore this scatter interactively →