Inflammatory response to antigenic stimulus

Across TCGA patient cohorts, RNA activity of the Inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LCP2, BIN2, and PLEK, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inflammatory response to antigenic stimulus activity versus LCP2 in OV (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LCP2 →	+0.829	+0.200	.005	.001	3	10
HNSC	BIN2 →	+0.777	+0.208	.001	<.001	3	9
OV	PLEK →	+1.076	+0.161	.001	.002	3	9
HNSC	ARHGAP9 →	+0.731	+0.148	.001	.008	3	9
GBM	BCL2A1 →	+1.156	+0.124	<.001	.007	3	9
GBM	ITGAX →	+0.787	+0.203	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002437 vs LCP2 — OV

Explore this scatter interactively →