Immune complex clearance

Across TCGA patient cohorts, RNA activity of the Immune complex clearance pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN6, CD4, and CD48, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immune complex clearance activity versus SEPTIN6 in LSCC (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEPTIN6 →	+0.541	+0.133	<.001	<.001	3	7
PDAC	CD4 →	+0.558	+0.101	<.001	<.001	3	7
HNSC	CD48 →	+0.750	+0.278	<.001	.001	3	7
LSCC	DENND1C_S596 →	+0.717	+0.107	<.001	<.001	3	7
LSCC	DOCK2 →	+0.629	+0.127	<.001	<.001	3	7
LSCC	EVI2B_S268 →	+1.004	+0.115	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002434 vs SEPTIN6 — LSCC

Explore this scatter interactively →