Immune complex clearance

Across TCGA patient cohorts, RNA activity of the Immune complex clearance pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELFN1-AS1, STK32C, and PRKAR1B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immune complex clearance activity versus ELFN1-AS1 in UCEC (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ELFN1-AS1 →	-0.792	-0.410	<.001	.005	3	3
LSCC	STK32C →	-0.321	-0.299	.004	.006	3	3
LSCC	PRKAR1B →	-0.463	-0.348	<.001	.002	3	3
UCEC	NPC2 →	+0.524	+0.456	.005	.001	3	2
UCEC	RNY3P16 →	-1.528	-0.480	.006	.006	3	2
UCEC	NIFKP4 →	-0.591	-0.532	.007	.006	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002434 vs ELFN1-AS1 — UCEC

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