Immune complex clearance

Across TCGA cell cohorts, RNA activity of the Immune complex clearance pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZRSR2, CDC14B, and CRX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZRSR2 grouped by Immune complex clearance-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZRSR2 →	-0.313	-0.211	.002	.007	3	4
KIDNEY	CDC14B →	+0.322	+0.259	.003	.006	3	3
LUNG_SCLC	CRX →	-0.153	-1.949	.002	<.001	3	3
LUNG_SCLC	SLC6A7 →	-0.316	-1.579	.002	.008	3	3
LUNG_SCLC	FAM182A →	-0.304	-2.076	<.001	<.001	3	3
LUNG_SCLC	CITED2 →	-0.137	-2.046	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZRSR2 by Immune complex clearance activity — KIDNEY

Explore this box plot interactively →