Immune response-regulating cell surface receptor signaling pathway involved in phagocytosis

pathway activity — cross-omics
GO:0002433Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Immune response-regulating cell surface receptor signaling pathway involved in phagocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01147, CSF3R, and NME8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCLINC01147 →+0.605+0.223<.001<.00136
LSCCCSF3R →+1.551+0.391<.001<.00136
HNSCNME8 →+0.422+0.166<.001<.00135
LSCCTLR8 →+0.631+0.245<.001<.00135
HNSCFASLG →+1.460+0.264<.001.00135
LSCCSASH3 →+0.692+0.289<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration