Fc receptor mediated stimulatory signaling pathway

Across TCGA cell cohorts, RNA activity of the Fc receptor mediated stimulatory signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOD3, GP5, and RPL7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOD3 grouped by Fc receptor mediated stimulatory signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SOD3 →	+0.295	+0.153	.003	.004	3	5
LUNG_NSCLC_LUSC	GP5 →	-0.128	-0.076	.008	.002	3	5
SOFT_TISSUE	RPL7 →	-0.392	-0.119	.003	.003	3	4
BLOOD_Lymphoma	INPP4A →	-0.338	-0.140	.002	.004	3	4
BREAST	GDAP2 →	+0.278	+0.092	<.001	.003	3	4
LUNG_SCLC	SENP7 →	-0.239	-0.127	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOD3 by Fc receptor mediated stimulatory signaling pathway activity — BLOOD_Myeloma

Explore this box plot interactively →