Fc receptor mediated stimulatory signaling pathway

Across TCGA cell cohorts, RNA activity of the Fc receptor mediated stimulatory signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VASH1, COX4I1, and PACS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fc receptor mediated stimulatory signaling pathway activity versus VASH1 in SOFT_TISSUE (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	VASH1 →	+1.999	+1.935	.004	<.001	3	5
SOFT_TISSUE	COX4I1 →	-0.529	-1.535	.003	.006	3	5
SOFT_TISSUE	PACS2 →	+1.100	+2.147	<.001	<.001	3	5
BLOOD_Lymphoma	NCAPH →	+0.681	+1.022	.004	<.001	3	4
BLOOD_Lymphoma	TBC1D31 →	+0.954	+1.292	.001	<.001	3	4
BLOOD_Lymphoma	EOMES →	+1.662	+0.867	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002431 vs VASH1 — SOFT_TISSUE

Explore this scatter interactively →