Complement receptor mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Complement receptor mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF292, KANSL3, and WDR54, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF292 grouped by Complement receptor mediated signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF292 →	+0.952	+0.360	.002	.002	3	5
LUNG_SCLC	KANSL3 →	+0.616	+0.323	.001	.005	3	4
BLOOD_Leukemia	WDR54 →	+2.019	+1.298	.001	<.001	3	4
STOMACH	ABCB6 →	+2.010	+0.399	<.001	<.001	3	3
STOMACH	MAD2L2 →	+1.149	+0.305	.001	.001	3	3
LUNG_NSCLC_LUSC	PAIP2 →	+1.383	+0.331	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF292 by Complement receptor mediated signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →