Antigen processing and presentation of peptide antigen via MHC class Ib

Across TCGA cell cohorts, RNA activity of the Antigen processing and presentation of peptide antigen via MHC class Ib pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDND1, UBL3, and NDUFV2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLDND1 grouped by Antigen processing and presentation of peptide antigen via MHC class Ib-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CLDND1 →	-0.741	-0.858	.003	.009	3	5
OVARY	UBL3 →	+0.971	+0.863	.004	.002	3	4
OVARY	NDUFV2 →	+0.652	+0.683	.001	.004	3	4
KIDNEY	C2orf81 →	+1.067	+1.122	.004	.004	3	4
BLOOD_Leukemia	RELB →	-1.059	-0.723	.001	.004	3	3
STOMACH	RIDA →	+1.348	+1.235	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLDND1 by Antigen processing and presentation of peptide antigen via MHC class Ib activity — SOFT_TISSUE

Explore this box plot interactively →