Natural killer cell mediated immune response to tumor cell

pathway activity — cross-omics
GO:0002423Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Natural killer cell mediated immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR6851, SLC25A18P1, and RNA5SP303, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECMIR6851 →-0.719-0.716.003<.00133
LSCCSLC25A18P1 →-0.059-0.649.008.00832
LSCCRNA5SP303 →-0.358-0.451.009.00532
OVPSMD2 →-0.364-0.488.007.00632
OVERICH3 →-0.505-0.909.005<.00123
OVHNRNPA1P9 →+0.090+0.575.001.00432
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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