Immune response to tumor cell

Across TCGA patient cohorts, RNA activity of the Immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOK3, HAVCR2, and RTN4RL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immune response to tumor cell activity versus DOK3 in LSCC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOK3 →	+0.472	+0.190	.001	.003	3	5
GBM	HAVCR2 →	+0.933	+0.162	<.001	<.001	3	5
CCRCC	RTN4RL1 →	-0.816	-0.432	.005	.002	3	5
LSCC	IL2RB →	+0.752	+0.263	<.001	<.001	3	5
LSCC	IRF1 →	+0.747	+0.273	<.001	<.001	3	5
GBM	TRPM2 →	+0.632	+0.137	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002418 vs DOK3 — LSCC

Explore this scatter interactively →