Immune response to tumor cell

Across TCGA cell cohorts, RNA activity of the Immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSC5D, SFXN4, and FKBP14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immune response to tumor cell activity versus SSC5D in CNS (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SSC5D →	+2.977	+0.138	.002	.001	2	4
CNS	SFXN4 →	-0.922	-0.137	.003	.006	3	3
CNS	FKBP14 →	+1.355	+0.142	<.001	<.001	3	2
CNS	TENT5A →	+1.842	+0.142	<.001	<.001	3	2
CNS	MARK1 →	-2.072	-0.096	.003	.007	3	2
CNS	P3H1 →	+1.312	+0.110	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002418 vs SSC5D — CNS

Explore this scatter interactively →