Myeloid dendritic cell chemotaxis

pathway activity — cross-omics
GO:0002408Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Myeloid dendritic cell chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMHD1, SPN_S355, and TRAF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCSAMHD1 →+0.587+0.157<.001<.001310
OVSPN_S355 →+1.302+0.150<.001<.001310
OVTRAF1 →+0.784+0.097.003<.001310
GBMWAS →+0.555+0.202<.001<.001310
OVWDFY4 →+0.573+0.115<.001<.001310
OVWIPF1 →+0.523+0.123<.001<.001310
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration