Myeloid dendritic cell chemotaxis

pathway activity — cross-omics
GO:0002408Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Myeloid dendritic cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A11, ARHGEF5, and SSBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCS100A11 →+0.692+0.638<.001<.00135
LSCCARHGEF5 →+0.942+1.142<.001<.00135
CCRCCSSBP1 →+0.403+0.582<.001.00534
LSCCHTATIP2 →+0.501+0.718.002<.00134
LSCCPRRG4 →+0.700+0.568<.001<.00134
LSCCZC3HAV1L →+0.648+0.851.006.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration