Dendritic cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Dendritic cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD48, IGHM, and BIN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic cell chemotaxis activity versus CD48 in LSCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD48 →	+0.721	+0.715	<.001	.006	3	5
UCEC	IGHM →	+2.318	+0.284	<.001	.002	3	4
LSCC	BIN2 →	+0.763	+0.775	<.001	.002	3	4
GBM	FCER1G →	+0.911	+1.087	<.001	<.001	3	4
GBM	CCR5 →	+0.761	+1.111	<.001	<.001	3	4
GBM	ARNT2 →	-0.444	-0.915	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002407 vs CD48 — LSCC

Explore this scatter interactively →