Dendritic cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Dendritic cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CROCC, TRAFD1, and TLN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CROCC grouped by Dendritic cell chemotaxis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CROCC →	-1.983	-2.062	<.001	.002	3	6
BONE	TRAFD1 →	+1.092	+1.789	.009	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	TLN2 →	-1.218	-1.174	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	H4C3 →	-0.707	-1.155	.001	<.001	3	4
LUNG_NSCLC_LUAD	FBXO33 →	-0.624	-0.698	<.001	.009	3	4
LARGE_INTESTINE	RALGPS1 →	+0.717	+0.772	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CROCC by Dendritic cell chemotaxis activity — BLOOD_Lymphoma

Explore this box plot interactively →