Dendritic cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Dendritic cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1L, P2RY8, and PLEKHN1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic cell chemotaxis activity versus PPM1L in LARGE_INTESTINE (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPM1L →	+0.944	+0.162	.007	.005	3	3
LARGE_INTESTINE	P2RY8 →	-0.169	-0.177	.005	.006	3	3
LARGE_INTESTINE	PLEKHN1 →	-1.831	-0.220	.005	.004	3	3
SKIN	EXOSC8 →	+0.902	+0.279	.002	.006	3	3
SKIN	TRIM47 →	-1.924	-0.267	.003	.005	3	3
BREAST	HRH1 →	-1.551	-0.210	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002407 vs PPM1L — LARGE_INTESTINE

Explore this scatter interactively →