Dendritic cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Dendritic cell chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMGB1, ZNF207, and SGTA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic cell chemotaxis activity versus HMGB1 in PANCREAS (Pearson r = 0.81).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HMGB1 →	+1.847	+0.412	<.001	<.001	3	6
PANCREAS	ZNF207 →	+1.376	+0.476	.003	<.001	3	5
STOMACH	SGTA →	+2.054	+0.191	<.001	.001	3	5
BONE	CXCR4 →	-1.401	-0.298	<.001	.003	2	6
STOMACH	SUGT1 →	+1.527	+0.191	<.001	.001	3	4
OESOPHAGUS	SH3GL1 →	+1.230	+0.215	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002407 vs HMGB1 — PANCREAS

Explore this scatter interactively →