Immunoglobulin production involved in immunoglobulin-mediated immune response

Across TCGA patient cohorts, RNA activity of the Immunoglobulin production involved in immunoglobulin-mediated immune response pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IPO9, CEP170, and YME1L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immunoglobulin production involved in immunoglobulin-mediated immune response activity versus IPO9 in UCEC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IPO9 →	+0.311	+0.054	<.001	.001	3	5
LSCC	CEP170 →	+0.215	+0.032	.004	<.001	3	5
BRCA	YME1L1 →	-0.245	-0.022	<.001	<.001	3	5
COAD	CLPX →	-0.114	-0.013	.007	.003	3	5
HNSC	RIN1 →	-0.441	-0.051	<.001	<.001	3	4
LSCC	RPL26 →	-0.365	-0.033	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002381 vs IPO9 — UCEC

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