Immunoglobulin production involved in immunoglobulin-mediated immune response

Across TCGA cell cohorts, RNA activity of the Immunoglobulin production involved in immunoglobulin-mediated immune response pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL5, DEPDC1, and STX11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHL5 grouped by Immunoglobulin production involved in immunoglobulin-mediated immune response-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KLHL5 →	+2.226	+0.206	.003	.003	2	5
STOMACH	DEPDC1 →	+0.825	+0.299	.009	.003	3	4
LUNG_NSCLC_LUAD	STX11 →	+0.871	+0.196	.004	.007	3	4
LARGE_INTESTINE	MTO1 →	+0.690	+0.170	.006	.006	2	4
LARGE_INTESTINE	C22orf46 →	+1.115	+0.189	<.001	.001	3	3
SOFT_TISSUE	UMAD1 →	+0.840	+0.273	.008	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHL5 by Immunoglobulin production involved in immunoglobulin-mediated immune response activity — URINARY_TRACT

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