Immunoglobulin production involved in immunoglobulin-mediated immune response

Across TCGA cell cohorts, RNA activity of the Immunoglobulin production involved in immunoglobulin-mediated immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRPPRC, ASRGL1, and SETD4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immunoglobulin production involved in immunoglobulin-mediated immune response activity versus LRPPRC in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LRPPRC →	+0.730	+0.163	<.001	<.001	3	5
STOMACH	ASRGL1 →	+2.095	+0.178	.002	.008	3	5
LUNG_NSCLC_LUSC	SETD4 →	+0.607	+0.285	.007	.006	3	5
LUNG_SCLC	DNPH1 →	+1.058	+0.117	.006	<.001	2	6
BREAST	TBPL1 →	+0.827	+0.193	<.001	<.001	3	5
BREAST	TMEM229B →	-1.618	-0.192	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002381 vs LRPPRC — LUNG_NSCLC_LUAD

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