Immunoglobulin production

Across TCGA patient cohorts, RNA activity of the Immunoglobulin production pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAG3, TICRR, and ITGAX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immunoglobulin production activity versus LAG3 in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LAG3 →	+0.907	+0.184	<.001	.001	3	5
LUAD	TICRR →	+0.701	+0.201	.001	.001	3	4
LUAD	ITGAX →	+0.848	+0.278	<.001	<.001	3	4
LUAD	DOK3 →	+0.619	+0.195	<.001	.002	3	4
LUAD	LILRB4 →	+0.687	+0.179	.002	.005	3	4
LUAD	IGHV1-69 →	+2.366	+0.240	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002377 vs LAG3 — BRCA

Explore this scatter interactively →