Immunoglobulin production

Across TCGA cell cohorts, RNA activity of the Immunoglobulin production pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIZ1, XPO4, and CHTOP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CIZ1 grouped by Immunoglobulin production-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CIZ1 →	+1.023	+0.163	<.001	<.001	3	5
URINARY_TRACT	XPO4 →	+0.697	+0.197	.007	.008	3	4
URINARY_TRACT	CHTOP →	+1.004	+0.173	.001	<.001	3	4
URINARY_TRACT	GRPEL2 →	+0.710	+0.189	<.001	.007	3	4
URINARY_TRACT	NBPF9 →	+1.492	+0.191	<.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	RAD51AP2 →	+0.284	+0.191	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CIZ1 by Immunoglobulin production activity — KIDNEY

Explore this box plot interactively →