Myeloid dendritic cell cytokine production

pathway activity — cross-omics
GO:0002372Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Myeloid dendritic cell cytokine production pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD1B_S134, UTP18, and WDR75, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADRPRD1B_S134 →+0.458+0.046<.001.00136
LSCCUTP18 →+0.250+0.061<.001<.00136
UCECWDR75 →+0.348+0.066<.001.00136
HNSCDDX18 →+0.350+0.085<.001<.00136
LSCCDDX56 →+0.296+0.059<.001<.00136
LSCCDDX27 →+0.345+0.065<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration