Myeloid dendritic cell cytokine production

pathway activity — cross-omics
GO:0002372Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Myeloid dendritic cell cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MOAP1, FABP3, and CEP55, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECMOAP1 →-0.727-0.186.001.00435
BRCAFABP3 →-0.543-0.159<.001<.00134
LUADCEP55 →+0.770+0.167.005.00434
UCECRMDN3 →-0.369-0.183.004<.00134
UCECMIEF2 →-0.557-0.178.005.00334
BRCABAIAP2-DT →-0.695-0.181<.001.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration