"CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation"
pathway activity — cross-omics
GO:0002361Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts
Across TCGA patient cohorts, RNA activity of the "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.
The most reproducible pathway-associated proteins across cancer lineages are MZB1, SEPTIN1, and CD38, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.
Each partner is linked to its corresponding Q-omics profile.
Pathway-associated proteins by consensus
Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.