T cell lineage commitment

Across TCGA patient cohorts, RNA activity of the T cell lineage commitment pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CORO1A, LCP1, and ARHGAP9_S475, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell lineage commitment activity versus CORO1A in LSCC (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CORO1A →	+0.669	+0.082	<.001	<.001	3	9
LSCC	LCP1 →	+0.651	+0.084	<.001	<.001	3	9
LSCC	ARHGAP9_S475 →	+0.809	+0.079	<.001	<.001	3	9
LSCC	PLCG2 →	+0.669	+0.078	<.001	<.001	3	9
LSCC	PLEKHO2 →	+0.374	+0.078	<.001	<.001	3	9
LSCC	RCSD1 →	+0.643	+0.080	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002360 vs CORO1A — LSCC

Explore this scatter interactively →