T cell lineage commitment

Across TCGA patient cohorts, RNA activity of the T cell lineage commitment pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEK, ARHGAP30, and TNFRSF1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell lineage commitment activity versus PLEK in GBM (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLEK →	+0.744	+0.266	.004	.004	3	7
LUAD	ARHGAP30 →	+0.426	+0.155	.001	.005	3	7
GBM	TNFRSF1B →	+0.744	+0.262	.002	.005	3	6
HNSC	LILRB1 →	+0.736	+0.318	<.001	.003	2	7
PDAC	ARHGAP9 →	+0.562	+0.477	<.001	.002	3	6
HNSC	MYO1F →	+0.580	+0.354	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002360 vs PLEK — GBM

Explore this scatter interactively →