T cell lineage commitment

Across TCGA cell cohorts, RNA activity of the T cell lineage commitment pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHC2, INTS6L, and MAD2L2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHC2 grouped by T cell lineage commitment-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PHC2 →	-1.303	-0.950	.006	.004	2	5
UPPER_AERODIGESTIVE_TRACT	INTS6L →	-1.188	-0.311	.009	.004	3	4
LUNG_SCLC	MAD2L2 →	-1.551	-1.299	<.001	.002	3	3
LUNG_SCLC	KIF15 →	-0.867	-1.173	.006	.001	3	3
LUNG_SCLC	KATNA1 →	-0.761	-1.194	.003	.001	3	3
BLOOD_Myeloma	CTNNA1 →	-1.314	-0.405	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHC2 by T cell lineage commitment activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →