T cell lineage commitment

Across TCGA cell cohorts, RNA activity of the T cell lineage commitment pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEATR3, PSG5, and IRAK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell lineage commitment activity versus HEATR3 in OVARY (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HEATR3 →	-0.749	-1.064	.003	.001	3	4
BREAST	PSG5 →	+1.556	+0.903	.001	.007	3	4
STOMACH	IRAK2 →	+1.768	+1.052	.007	.009	3	4
URINARY_TRACT	SLC4A11 →	-2.112	-1.301	.001	<.001	3	4
OVARY	ABTB1 →	+1.201	+1.109	<.001	<.001	3	3
OVARY	BUD13 →	-0.620	-1.013	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002360 vs HEATR3 — OVARY

Explore this scatter interactively →