Defense response to tumor cell

Across TCGA patient cohorts, RNA activity of the Defense response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPTX2, RASD2, and RPGRIP1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Defense response to tumor cell activity versus NPTX2 in LSCC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NPTX2 →	-1.192	-0.599	<.001	.003	3	4
LSCC	RASD2 →	-0.732	-0.515	.006	.001	3	3
LSCC	RPGRIP1L →	-0.365	-0.757	.007	<.001	3	3
LSCC	TMEM169 →	-0.325	-0.537	.005	.008	3	3
LUAD	HOPX →	+1.078	+0.532	.003	.005	3	3
LUAD	KAAG1 →	-0.172	-0.636	.006	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002357 vs NPTX2 — LSCC

Explore this scatter interactively →