Defense response to tumor cell

Across TCGA cell cohorts, RNA activity of the Defense response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDX2, ZNF414, and MAGEH1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Defense response to tumor cell activity versus PRDX2 in SKIN (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRDX2 →	+4.261	+1.463	<.001	.001	3	11
LIVER	ZNF414 →	+0.812	+0.360	.005	<.001	3	5
OESOPHAGUS	MAGEH1 →	-1.722	-0.784	.008	.006	2	6
SKIN	RAB3A →	+1.038	+0.819	.008	.005	3	4
PANCREAS	MYB →	+1.477	+0.264	.001	.001	3	4
BREAST	TWSG1 →	-1.498	-0.241	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002357 vs PRDX2 — SKIN

Explore this scatter interactively →