Response to tumor cell

Across TCGA cell cohorts, RNA activity of the Response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB8, HLA-A, and SPATA6L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to tumor cell activity versus PSMB8 in SOFT_TISSUE (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PSMB8 →	+4.984	+1.713	<.001	.003	3	6
BREAST	HLA-A →	+2.611	+0.300	.007	<.001	2	7
STOMACH	SPATA6L →	+1.351	+0.162	.002	.009	3	5
BREAST	TAP1 →	+1.743	+0.289	<.001	<.001	3	5
BREAST	NLRC5 →	+1.697	+0.259	<.001	.001	3	5
SKIN	DNAI1 →	-0.221	-0.392	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002347 vs PSMB8 — SOFT_TISSUE

Explore this scatter interactively →