Mature B cell differentiation

Across TCGA cell cohorts, RNA activity of the Mature B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC17, CCL24, and BTRC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC17 grouped by Mature B cell differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCDC17 →	+0.401	+1.468	.001	<.001	3	3
OESOPHAGUS	CCL24 →	+0.575	+0.853	.007	.004	3	3
BREAST	BTRC →	-0.612	-0.862	<.001	.002	3	3
BLOOD_Lymphoma	CD82 →	+5.743	+1.629	<.001	<.001	2	4
URINARY_TRACT	DCLRE1C →	-0.759	-1.425	.007	.005	3	3
BLOOD_Leukemia	ASS1 →	+4.409	+1.164	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC17 by Mature B cell differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →