Mature B cell differentiation

Across TCGA cell cohorts, RNA activity of the Mature B cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SS18, EDN1, and PSMD5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SS18 grouped by Mature B cell differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SS18 →	+0.224	+0.342	.003	<.001	3	3
PANCREAS	EDN1 →	+0.227	+1.308	.001	<.001	3	3
STOMACH	PSMD5 →	+0.100	+1.811	.009	.005	3	3
STOMACH	ARRB1 →	-0.105	-1.879	.001	<.001	3	3
STOMACH	PIGU →	-0.247	-1.929	.001	<.001	3	2
CNS	SERGEF →	-0.167	-0.941	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SS18 by Mature B cell differentiation activity — SKIN

Explore this box plot interactively →