Mature B cell differentiation

Across TCGA cell cohorts, RNA activity of the Mature B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM245, RAD23B, and INPP5E, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mature B cell differentiation activity versus TMEM245 in PANCREAS (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TMEM245 →	-0.690	-1.166	.001	.001	3	4
PANCREAS	RAD23B →	-0.896	-1.293	.003	.008	3	4
STOMACH	INPP5E →	-1.134	-1.404	.001	.009	2	5
STOMACH	PPRC1 →	-1.113	-1.914	.001	<.001	3	4
STOMACH	TAOK2 →	-0.811	-1.738	.007	<.001	3	4
STOMACH	CIP2A →	-1.378	-1.738	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002335 vs TMEM245 — PANCREAS

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