Pro-B cell differentiation

Across TCGA patient cohorts, RNA activity of the Pro-B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP10, RPLP0P2, and SIAE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pro-B cell differentiation activity versus DUSP10 in BRCA (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DUSP10 →	-0.787	-0.485	.001	.001	3	4
GBM	RPLP0P2 →	+0.347	+0.469	.008	.005	3	3
BRCA	SIAE →	-0.603	-0.601	.007	.003	3	3
LUAD	KATNA1 →	+0.227	+0.270	.009	.006	3	3
LUAD	IQCJ-SCHIP1-AS1 →	+0.484	+0.258	.001	.004	3	3
LUAD	ASAP1-IT2 →	+0.553	+0.272	<.001	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002328 vs DUSP10 — BRCA

Explore this scatter interactively →