Pro-B cell differentiation

Across TCGA cell cohorts, RNA activity of the Pro-B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFLNB, SACS, and ACTG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RFLNB grouped by Pro-B cell differentiation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RFLNB →	-2.199	-1.528	.008	<.001	3	5
CNS	SACS →	-0.917	-1.085	.002	<.001	3	4
LIVER	ACTG1 →	-1.565	-1.455	.003	.008	3	4
BONE	TCP11L1 →	-1.404	-1.379	.005	.006	2	5
KIDNEY	RGCC →	-0.500	-1.281	<.001	<.001	3	4
KIDNEY	MRC2 →	-2.584	-1.275	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RFLNB by Pro-B cell differentiation activity — KIDNEY

Explore this box plot interactively →