Pro-B cell differentiation

Across TCGA cell cohorts, RNA activity of the Pro-B cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC30A1, NDUFS8, and SNAPIN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC30A1 grouped by Pro-B cell differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC30A1 →	+0.122	+0.518	.001	.007	3	3
LIVER	NDUFS8 →	-0.455	-1.777	.004	<.001	3	3
CNS	SNAPIN →	-0.130	-0.467	<.001	.004	3	3
SOFT_TISSUE	RABL6 →	+0.233	+1.340	.008	<.001	3	3
CNS	POMT2 →	+0.207	+0.826	.001	.004	3	2
URINARY_TRACT	PTPRC →	+0.283	+1.738	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC30A1 by Pro-B cell differentiation activity — OVARY

Explore this box plot interactively →