Immature B cell differentiation

Across TCGA patient cohorts, RNA activity of the Immature B cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAB1, WAS, and RRP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immature B cell differentiation activity versus STAB1 in GBM (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAB1 →	+0.495	+0.053	<.001	.001	3	9
GBM	WAS →	+0.449	+0.062	.003	.001	3	8
BRCA	RRP1 →	-0.455	-0.073	<.001	<.001	3	7
LSCC	SELENOM →	+0.322	+0.064	<.001	<.001	3	7
LSCC	SNX9 →	+0.273	+0.081	.003	<.001	3	7
LSCC	TLN1 →	+0.224	+0.073	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002327 vs STAB1 — GBM

Explore this scatter interactively →