Immature B cell differentiation

Across TCGA cell cohorts, RNA activity of the Immature B cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF43, CHRNA6, and RALGPS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF43 grouped by Immature B cell differentiation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZNF43 →	+0.218	+0.153	<.001	.004	3	5
BLOOD_Lymphoma	CHRNA6 →	-0.307	-0.181	.003	<.001	3	5
BLOOD_Leukemia	RALGPS2 →	+0.520	+0.154	.001	<.001	3	5
BREAST	NAV3 →	+0.135	+0.104	.007	.001	3	4
BREAST	HUWE1 →	-0.400	-0.118	<.001	.002	3	4
BREAST	POMT2 →	-0.136	-0.069	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF43 by Immature B cell differentiation activity — KIDNEY

Explore this box plot interactively →